Antimicrobial resistance is responsible for some 700 000 deaths each year worldwide*. In relation to this phenomenon, a team of researchers from IRD and CIRAD have raised the alarm regarding the development of antimicrobial-resistant bacteria in aquaculture, which is affecting fish production and human health worldwide. Their study, published in Nature Communications on 20th April 2020, established for the first time a link between global warming and an increased risk of antimicrobial resistance, and warned against inappropriate use of antibiotics.

Aquaculture – rearing aquatic organisms such as fish** and shellfish – plays a vital role in food security in many countries (it supplies more than half of the aquatic animals consumed by humans worldwide). It is particularly important for developing countries, for instance in Asia, which accounts for 90% of global output.

Fish farmers use large quantities of antimicrobials to treat or prevent disease on their farms. However, when used inappropriately, antimicrobials are ineffective and foster the development of resistant bacteria.

An index to assess the risks of antimicrobial resistance in aquaculture

Researchers from IRD and CIRAD belonging to the Institute of Evolution Sciences of Montpellier's Fish Diversity and Aquaculture team (DIVA, UMR ISEM) examined data from more than 400 scientific articles referring to over 10 000 bacteria of aquacultural origin from 40 countries. That meta-analysis allowed them to study the effect of temperature on the mortality rate of aquatic animals infected with pathogenic bacteria commonly found in aquaculture. They then conducted a systematic review on the abundance of resistant bacteria found on fish farms and calculated the Multi-Antibiotic Resistance (MAR) index for 40 countries.

Map showing multi-antibiotic resistance worldwide. The index is calculated by determining the ratio between the number of antibiotics to which an isolate is resistant and the total of antibiotics to which it was exposed (an index >0.2 indicates high antibiotic contamination).

The map shows high antimicrobial resistance indexes for 40 countries that account for 93% of global aquacultural production. This is the case for Indonesia (index: 0.355) and China (index: 0.325), for instance.

Global warming is partly responsible

"Our results show that global warming promotes the development of pathogenic bacteria, hence disease development on fish farms", Rodolphe Gozlan, an IRD specialist in biodiversity-health relations, explains.

Aquatic bacteria are in effect temperature-sensitive. "Global warming will therefore push up mortality rates on fish farms, which is likely to mean increased antibiotic use", says Miriam Reverter, a post-doctoral student at IRD, and as the study showed, antimicrobial resistance is already a reality in several countries among those that are highly vulnerable to climate change.

A threat to animal and human health

The study's authors raise the alarm about the consequences of inappropriate antibiotic use, for both the sustainability of aquaculture and human health. "Resistant bacteria in aquaculture can either spread or transmit their resistance genes to non-resistant bacteria that infect humans, thus causing diseases that are difficult to treat in both animals and humans", Samira Sarter, a microbiologist with CIRAD, explains.

These health risks linked to antibiotic use are not restricted to aquaculture. They also apply to terrestrial farms. "Some 60% of the infectious diseases that currently affect humans are of animal origin. If a resistant bacterium or its genes were to be transmitted to humans, and existing antibiotics were ineffective, we could face a steep rise in mortality rates as a result of antimicrobial resistance."

Finding alternatives to antibiotics

"We urgently need to help producers in the global South find alternatives to treat and prevent disease on fish farms. This means encouraging research that makes use of the One Health or EcoHealth approaches, i.e. that is multi-disciplinary and multi-sector", Rodolphe Gozlan stresses. Work has shown that certain plants are highly effective for boosting disease immunity in fish. Their use on fish farms could help reduce antibiotic use. Alongside this, researchers are also working to develop more resilient aquaculture systems based on the principles of agroecology, in the aim of reducing disease rates.

Reference

Miriam Reverter, Samira Sarter, Domenico Caruso, Jean-Christophe Avarre, Marine Combe, Elodie Pepey, Laurent Pouyaud, Sarahi Vega-Heredía, Hugues de Verdal, Rodolphe E. Gozlan. Aquaculture at the crossroads of global warming and antimicrobial resistance, Nature Communications, 20 April 2020

* Review on Antimicrobial Resistance, 2014
** 87% of farmed fish are freshwater species

Category: Science

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